Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0022260
http://purl.obolibrary.org/obo/HINO_0022260
Preferred Name

Regulation of IFNG signaling
Definitions
Authored: Garapati, P V, 2010-06-08 At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade. Edited: Garapati, P V, 2010-06-08 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17
Type http://www.w3.org/2002/07/owl#Class

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label
Regulation of IFNG signaling
comment
Authored: Garapati, P V, 2010-06-08
At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.
Edited: Garapati, P V, 2010-06-08
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17
prefLabel
Regulation of IFNG signaling
located_in
definition source
Pubmed12645661
Reactome, http://www.reactome.org
Pubmed10526574
Pubmed18031232
prefixIRI
HINO:0022260
seeAlso
GENE ONTOLOGYGO:0060334
Reactome Database ID Release 43877312
ReactomeREACT_24980
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type
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