loading...| Preferred Name | Interferon gamma signaling | |
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| Definitions |
Authored: Garapati, P V, 2010-06-08 Interferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by interacting with the specific IFN-gamma receptor (IFNGR). IFNGR consists of two chains, namely IFNGR1 (also known as the IFNGR alpha chain) and IFNGR2 (also known as the IFNGR beta chain). IFNGR1 is the ligand binding receptor and is required but not sufficient for signal transduction, whereas IFNGR2 do not bind IFNG independently but mainly plays a role in IFNG signaling and is generally the limiting factor in IFNG responsiveness. Both IFNGR chains lack intrinsic kinase/phosphatase activity and thus rely on other signaling proteins like Janus-activated kinase 1 (JAK1), JAK2 and Signal transducer and activator of transcription 1 (STAT-1) for signal transduction. IFNGR complex in its resting state is a preformed tetramer and upon IFNG association undergoes a conformational change. This conformational change induces the phosphorylation and activation of JAK1, JAK2, and STAT1 which in turn induces genes containing the gamma-interferon activation sequence (GAS) in the promoter. Edited: Garapati, P V, 2010-06-08 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 |
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http://purl.obolibrary.org/obo/HINO_0022255 |
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| comment |
Authored: Garapati, P V, 2010-06-08 Interferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by interacting with the specific IFN-gamma receptor (IFNGR). IFNGR consists of two chains, namely IFNGR1 (also known as the IFNGR alpha chain) and IFNGR2 (also known as the IFNGR beta chain). IFNGR1 is the ligand binding receptor and is required but not sufficient for signal transduction, whereas IFNGR2 do not bind IFNG independently but mainly plays a role in IFNG signaling and is generally the limiting factor in IFNG responsiveness. Both IFNGR chains lack intrinsic kinase/phosphatase activity and thus rely on other signaling proteins like Janus-activated kinase 1 (JAK1), JAK2 and Signal transducer and activator of transcription 1 (STAT-1) for signal transduction. IFNGR complex in its resting state is a preformed tetramer and upon IFNG association undergoes a conformational change. This conformational change induces the phosphorylation and activation of JAK1, JAK2, and STAT1 which in turn induces genes containing the gamma-interferon activation sequence (GAS) in the promoter. Edited: Garapati, P V, 2010-06-08 Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17 |
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| definition source |
Pubmed14525967 Pubmed9143700 Reactome, http://www.reactome.org Pubmed18929502 Pubmed9462485 |
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Interferon gamma signaling |
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| prefixIRI |
HINO:0022255 |
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| prefLabel |
Interferon gamma signaling |
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| seeAlso |
Reactome Database ID Release 43877300 ReactomeREACT_25078 GENE ONTOLOGYGO:0060333 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0007171 http://purl.obolibrary.org/obo/HINO_0007172 http://purl.obolibrary.org/obo/HINO_0007112 http://purl.obolibrary.org/obo/HINO_0007114 http://purl.obolibrary.org/obo/HINO_0007113 http://purl.obolibrary.org/obo/HINO_0007110 http://purl.obolibrary.org/obo/HINO_0007115 http://purl.obolibrary.org/obo/HINO_0007111 http://purl.obolibrary.org/obo/HINO_0022260 http://purl.obolibrary.org/obo/HINO_0007108 |