loading...| Preferred Name | Interleukin receptor SHC signaling | |
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Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Phosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor complex. These phosphorylated tyrosines subsequently bind SH2 signaling proteins such as Grb2, Gab2 and SHIP that are involved in the regulation of different signaling pathways. Grb2 can associate with the guanosine diphosphate-guanosine triphosphate exchange factor Sos1, leading to Ras activation and regulation of cell proliferation. Downstream signals are mediated via the Raf-MEK-Erk pathway.Grb2 can also associate through Gab2 with PI3K and with SHIP.<br><br>Figure reproduced from Gu, H. et al. 2000. Mol. Cell. Biol. 20(19):7109-7120<br>Copyright American Society for Microbiology. All Rights Reserved. |
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http://purl.obolibrary.org/obo/HINO_0022230 |
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Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Phosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor complex. These phosphorylated tyrosines subsequently bind SH2 signaling proteins such as Grb2, Gab2 and SHIP that are involved in the regulation of different signaling pathways. Grb2 can associate with the guanosine diphosphate-guanosine triphosphate exchange factor Sos1, leading to Ras activation and regulation of cell proliferation. Downstream signals are mediated via the Raf-MEK-Erk pathway.Grb2 can also associate through Gab2 with PI3K and with SHIP. |
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| definition source |
Pubmed8947042 Pubmed10982827 Reactome, http://www.reactome.org Pubmed8084588 Pubmed8294403 |
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Interleukin receptor SHC signaling |
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HINO:0022230 |
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Interleukin receptor SHC signaling |
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Reactome Database ID Release 43912526 ReactomeREACT_23891 |
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http://purl.obolibrary.org/obo/HINO_0007002 http://purl.obolibrary.org/obo/HINO_0007004 http://purl.obolibrary.org/obo/HINO_0007000 http://purl.obolibrary.org/obo/HINO_0007006 http://purl.obolibrary.org/obo/HINO_0006994 |