Reviewed: Fitzgerald, Katherine A, 2012-11-13 Authored: Shamovsky, V, 2012-05-15 TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells [Kalai M et al 2002; Han KJ et al 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al 2012; He S et al 2011]. Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) [Kalai M et al 2002; Weber A et al 2010; Feoktistova M et al 2011, Tenev et al 2011]. Edited: Shamovsky, V, 2012-11-19

http://purl.obolibrary.org/obo/HINO_0021963

Reviewed: Fitzgerald, Katherine A, 2012-11-13

Authored: Shamovsky, V, 2012-05-15

TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells [Kalai M et al 2002; Han KJ et al 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al 2012; He S et al 2011]. Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) [Kalai M et al 2002; Weber A et al 2010; Feoktistova M et al 2011, Tenev et al 2011].

Edited: Shamovsky, V, 2012-11-19

Pubmed12181749

Reactome, http://www.reactome.org

Pubmed20019748

Pubmed15814722

Pubmed22421964

Pubmed21737330

Pubmed14739303

Pubmed21737329

TRIF-mediated programmed cell death

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0021963

TRIF-mediated programmed cell death

Reactome Database ID Release 432562578

ReactomeREACT_150361

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0009313

http://purl.obolibrary.org/obo/HINO_0009311

http://purl.obolibrary.org/obo/HINO_0009309