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Human Interaction Network Ontology
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June 27, 2014
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| Preferred Name | Elastin cross-linking by lysyl oxidase | |
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| Definitions |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Soluble monomers of tropoelastin are cross-linked by the oxidative deamination of lysine residues, catalyzed by lysyl oxidase (LOX). The first step in the cross linking reaction is the oxidative formation of the delta-aldehyde, known as alpha aminoadipic semialdehyde or allysine (Partridge 1963). Subsequent spontaneous reactions lead to the formation of cross-links through dehydrolysinonorleucine and allysine aldol, a trifunctional cross-link dehydromerodesmosine and two tetrafunctional cross-links desmosine and isodesmosine (Lucero & Kagan 2006), which are unique to elastin. Reviewed: Muiznieks, Lisa, 2012-11-02 |
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http://purl.obolibrary.org/obo/HINO_0021713 |
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| comment |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Soluble monomers of tropoelastin are cross-linked by the oxidative deamination of lysine residues, catalyzed by lysyl oxidase (LOX). The first step in the cross linking reaction is the oxidative formation of the delta-aldehyde, known as alpha aminoadipic semialdehyde or allysine (Partridge 1963). Subsequent spontaneous reactions lead to the formation of cross-links through dehydrolysinonorleucine and allysine aldol, a trifunctional cross-link dehydromerodesmosine and two tetrafunctional cross-links desmosine and isodesmosine (Lucero & Kagan 2006), which are unique to elastin. Reviewed: Muiznieks, Lisa, 2012-11-02
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| definition source |
Reactome, http://www.reactome.org Pubmed6123066 Pubmed16906757 Pubmed16909208
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Elastin cross-linking by lysyl oxidase
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| prefixIRI |
HINO:0021713
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| prefLabel |
Elastin cross-linking by lysyl oxidase
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| seeAlso |
ReactomeREACT_150459 EC Number: 1.4.3.13 Reactome Database ID Release 432129375
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