Link to this page
Human Interaction Network Ontology
| Preferred Name | Tropoelastin associates with microfibrils | |
| Synonyms |
|
|
| Definitions |
Elastin, the highly insoluble core protein of elastic fibers, is secreted as a soluble protein monomer referred to as tropoelastin. Under physiological conditions the monomers phase separate and coalesce into spherical packages (Clarke et al. 2006), a process known as coacervation. Packages of accumulated elastin are delivered to fibrillin-based fibres in a mechanism that is correlated with cell migration during embryonic development (Czirok et al. 2006). A transglutaminase cross-link between domain 4 of tropoelastin and domain 16 of fibrillin-1 may stabilize initial deposition (Clarke et al. 2005). Elastin is subsequently cross linked by members of the lysyl oxidase family via lysine residues, resulting in mature, insoluble fibres (Sato et al. 2007, Wise & Weiss 2009). Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Reviewed: Muiznieks, Lisa, 2012-11-02 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0021712 |
|
| comment |
Elastin, the highly insoluble core protein of elastic fibers, is secreted as a soluble protein monomer referred to as tropoelastin. Under physiological conditions the monomers phase separate and coalesce into spherical packages (Clarke et al. 2006), a process known as coacervation. Packages of accumulated elastin are delivered to fibrillin-based fibres in a mechanism that is correlated with cell migration during embryonic development (Czirok et al. 2006). A transglutaminase cross-link between domain 4 of tropoelastin and domain 16 of fibrillin-1 may stabilize initial deposition (Clarke et al. 2005). Elastin is subsequently cross linked by members of the lysyl oxidase family via lysine residues, resulting in mature, insoluble fibres (Sato et al. 2007, Wise & Weiss 2009). Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Reviewed: Muiznieks, Lisa, 2012-11-02
|
|
| definition source |
Pubmed18468477 Pubmed16331676 Pubmed16042404 Reactome, http://www.reactome.org Pubmed17459412 Pubmed16906757
|
|
| has input | ||
| has output | ||
| label |
Tropoelastin associates with microfibrils
|
|
| prefixIRI |
HINO:0021712
|
|
| prefLabel |
Tropoelastin associates with microfibrils
|
|
| seeAlso |
Reactome Database ID Release 432129353 ReactomeREACT_150146
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |