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Human Interaction Network Ontology
| Preferred Name | Collagen type VIII degradation by MMP1 | |
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| Definitions |
Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet's membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012).<br><br> Collagen type VIII can be degraded by MMP1 (Sage et al. 1983, 1984). Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2011-07-12 Reviewed: Sorsa, Timo, 2012-10-08 |
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http://purl.obolibrary.org/obo/HINO_0021682 |
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Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet's membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012).<br><br>
Collagen type VIII can be degraded by MMP1 (Sage et al. 1983, 1984). Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2011-07-12 Reviewed: Sorsa, Timo, 2012-10-08
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Pubmed2226849 Pubmed22002996 Pubmed9438378 Reactome, http://www.reactome.org Pubmed10428768 Pubmed6630235 Pubmed6694361
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Collagen type VIII degradation by MMP1
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HINO:0021682
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Collagen type VIII degradation by MMP1
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EC Number: 3.4.21 ReactomeREACT_150162 Reactome Database ID Release 431564169
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