Link to this page
Human Interaction Network Ontology
| Preferred Name | Collagen type VIII degradation by ELANE | |
| Synonyms |
|
|
| Definitions |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2011-07-12 Reviewed: Sorsa, Timo, 2012-10-08 Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemets membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012). Collagen type VIII can be degraded by neutrophil elastase (ELANE, ELA2; Kittelberger et al. 1992). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0021681 |
|
| comment |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2011-07-12 Reviewed: Sorsa, Timo, 2012-10-08 Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemets membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012).
Collagen type VIII can be degraded by neutrophil elastase (ELANE, ELA2; Kittelberger et al. 1992).
|
|
| definition source |
Pubmed2226849 Pubmed22002996 Pubmed9438378 Reactome, http://www.reactome.org Pubmed1515454 Pubmed10428768
|
|
| has input | ||
| has output | ||
| label |
Collagen type VIII degradation by ELANE
|
|
| prefixIRI |
HINO:0021681
|
|
| prefLabel |
Collagen type VIII degradation by ELANE
|
|
| seeAlso |
EC Number: 3.4.21 ReactomeREACT_150332 Reactome Database ID Release 432482180
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |