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Human Interaction Network Ontology
| Preferred Name | MFAP2, MFAP5 bind microfibrils | |
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| Definitions |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Microfibrils are composed largely of fibrillin but also contain covalently-linked microfibril associated glycoproteins MAGP-1 (MFAP2) and MAGP-2 (MFAP5). MFAP2 is a structural component of almost all vertebrate microfibrils (Gibson et al. 1989, Trask et al. 2000, Jensen et al. 2001). It appears to be important for tissue development and/or homeostasis, including regulation of bone remodelling and deposition of tissue fat (Weinbaum et al. 2008). The C-terminal half of MFAP2 is rich in cysteines and contains a matrix-binding domain that facilitates interactions with fibrillin (Weinbaum et al. 2008). The related MFAP5 similarly binds to microfibrils (Gibson et al. 1998) but with a restricted expression profile. Reviewed: Muiznieks, Lisa, 2012-11-02 |
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http://purl.obolibrary.org/obo/HINO_0021676 |
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| comment |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Microfibrils are composed largely of fibrillin but also contain covalently-linked microfibril associated glycoproteins MAGP-1 (MFAP2) and MAGP-2 (MFAP5). MFAP2 is a structural component of almost all vertebrate microfibrils (Gibson et al. 1989, Trask et al. 2000, Jensen et al. 2001). It appears to be important for tissue development and/or homeostasis, including regulation of bone remodelling and deposition of tissue fat (Weinbaum et al. 2008). The C-terminal half of MFAP2 is rich in cysteines and contains a matrix-binding domain that facilitates interactions with fibrillin (Weinbaum et al. 2008). The related MFAP5 similarly binds to microfibrils (Gibson et al. 1998) but with a restricted expression profile. Reviewed: Muiznieks, Lisa, 2012-11-02
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| definition source |
Pubmed10793130 Pubmed9671438 Pubmed11481325 Reactome, http://www.reactome.org Pubmed2647740 Pubmed18625713
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| label |
MFAP2, MFAP5 bind microfibrils
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| prefixIRI |
HINO:0021676
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| prefLabel |
MFAP2, MFAP5 bind microfibrils
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| seeAlso |
ReactomeREACT_150448 Reactome Database ID Release 432129385
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