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Human Interaction Network Ontology
| Preferred Name | Release of endostatin-like peptides | |
| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 18 Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Reviewed: Raleigh, Stewart, 2012-10-08 Collagens XV and XVIII are basement membrane associated collagens that can be cleaved to generate the antiangiogenic peptides restin (endostatin-XV) and endostatin (endostatin-XVIII), respectively (O'Reilly et al. 1997, Ramachandran et al. 1997, Sasaki et al. 2000). Endostatin fragments of differing molecular size (14-30 kDa) have been identified in vivo. Furthermore the C-terminal domains of several other collagens (IV, VIII, XIX) have anti-angiogenic and anti-tumoral activities (Ricard-Blum & Ballut 2011). Several proteases are able to generate endostatin from collagen XVIII including MMP-3, -7, -9, -13 and -20 and cathepsins B, V, S and L (Heljasvaara et al. 2005, Ma et al. 2007, Veillard et al. 2011). Endostatin inhibits proliferation of endothelial cells, angiogenesis and tumor growth in vivo (O'Reilly et al. 1997). Reviewed: Ricard-Blum, Sylvie, 2012-11-19 Reviewed: Kalamajski, Sebastian, 2012-10-08 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0021611 |
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| comment |
has a Stoichiometric coefficient of 18 Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Reviewed: Raleigh, Stewart, 2012-10-08 Collagens XV and XVIII are basement membrane associated collagens that can be cleaved to generate the antiangiogenic peptides restin (endostatin-XV) and endostatin (endostatin-XVIII), respectively (O'Reilly et al. 1997, Ramachandran et al. 1997, Sasaki et al. 2000). Endostatin fragments of differing molecular size (14-30 kDa) have been identified in vivo. Furthermore the C-terminal domains of several other collagens (IV, VIII, XIX) have anti-angiogenic and anti-tumoral activities (Ricard-Blum & Ballut 2011). Several proteases are able to generate endostatin from collagen XVIII including MMP-3, -7, -9, -13 and -20 and cathepsins B, V, S and L (Heljasvaara et al. 2005, Ma et al. 2007, Veillard et al. 2011). Endostatin inhibits proliferation of endothelial cells, angiogenesis and tumor growth in vivo (O'Reilly et al. 1997). Reviewed: Ricard-Blum, Sylvie, 2012-11-19 Reviewed: Kalamajski, Sebastian, 2012-10-08
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| definition source |
Pubmed9008168 Pubmed21896479 Reactome, http://www.reactome.org Pubmed10049780 Pubmed21196195 Pubmed15950618 Pubmed17251461 Pubmed12690120 Pubmed10966814
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| label |
Release of endostatin-like peptides
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| prefixIRI |
HINO:0021611
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| prefLabel |
Release of endostatin-like peptides
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| seeAlso |
Reactome Database ID Release 432213200 ReactomeREACT_150219
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