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Human Interaction Network Ontology
| Preferred Name | Prolysyl oxidase activation | |
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| Definitions |
Lysyl oxidase (LOX) is secreted to the extracellular space in an inactive, proenzyme form (proLOX). This is proteolytically cleaved between Gly168 and Asp169 generating the mature 32-kDa enzyme. The activating proteinase is Bone morphogenetic protein 1 (BMP1), also called Procollagen C-proteinase (Cronshaw et al. 1995, Panchenko et al. 1996). Other extracellular proteases, including the BMP1 variant mammalian tolloid, tolloid-like (TLL) 1 and TLL2 proteases cleave proLOX at the correct physiological site but with lower efficiency (Uzel et al. 2001). Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Reviewed: Raleigh, Stewart, 2012-10-08 Reviewed: Ricard-Blum, Sylvie, 2012-11-19 Reviewed: Kalamajski, Sebastian, 2012-10-08 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0021610 |
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| comment |
Lysyl oxidase (LOX) is secreted to the extracellular space in an inactive, proenzyme form (proLOX). This is proteolytically cleaved between Gly168 and Asp169 generating the mature 32-kDa enzyme. The activating proteinase is Bone morphogenetic protein 1 (BMP1), also called Procollagen C-proteinase (Cronshaw et al. 1995, Panchenko et al. 1996). Other extracellular proteases, including the BMP1 variant mammalian tolloid, tolloid-like (TLL) 1 and TLL2 proteases cleave proLOX at the correct physiological site but with lower efficiency (Uzel et al. 2001). Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Reviewed: Raleigh, Stewart, 2012-10-08 Reviewed: Ricard-Blum, Sylvie, 2012-11-19 Reviewed: Kalamajski, Sebastian, 2012-10-08
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| definition source |
Pubmed7864821 Pubmed11313359 Reactome, http://www.reactome.org Pubmed8636146
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| label |
Prolysyl oxidase activation
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| prefixIRI |
HINO:0021610
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| prefLabel |
Prolysyl oxidase activation
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| seeAlso |
ReactomeREACT_150462 Reactome Database ID Release 432022141 EC Number: 3.4.24
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