Reviewed: Freedman, LP, 2008-02-25 20:35:15 TRAP co-activator complex and assembly<br><br>The TRAP co-activator complex is a subset of 18 proteins from the set of at least 31 Mediator proteins that, in different combinations and in different contexts, form specific co-activator or "Adapter" complexes in human cells. These complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (reviewed in Maston, 2006 and Naar, 2001).<br><br>The TRAP complex was originally identified and named as a co-activator complex associated with the Thyroid Hormone Receptor member of the nuclear receptor family of transcription factors (Yuan, 1998). It was later determined that many of the components of the TRAP complex are also in the DRIP complex, and in the ARC complex.<br><br>The TRAP complex contains the following 14 proteins, which also are common to the DRIP and ARC complexes: MED1, MED4, MED6, MED7, MED10, MED12, MED13, MED14, MED16, MED17, MED23, MED24, CDK8, CycC.<br><br>The TRAP complex also contains 4 additional components, which are now called: MED20, MED27, MED30, and MED 31 in the unified nomenclature scheme (Bourbon, 2004).<br><br>In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator complex proteins in yeast, first identified by Kornberg and colleagues (Kelleher, 1990). The unified nomenclature system for these adapter / co-activator proteins now labels them Mediator 1 through Mediator 31 (Bourbon, 2004).<br><br>The order of addition of the TRAP proteins during complex assembly is not fully determined, and may vary in different cell contexts. Therefore, TRAP co-activator complex assembly is represented as a single reaction event, in which all 18 components assemble simultaneously into the TRAP co-activator complex.<br><br>

http://purl.obolibrary.org/obo/HINO_0019780

Reviewed: Freedman, LP, 2008-02-25 20:35:15

TRAP co-activator complex and assembly

The TRAP co-activator complex is a subset of 18 proteins from the set of at least 31 Mediator proteins that, in different combinations and in different contexts, form specific co-activator or "Adapter" complexes in human cells. These complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (reviewed in Maston, 2006 and Naar, 2001).

The TRAP complex was originally identified and named as a co-activator complex associated with the Thyroid Hormone Receptor member of the nuclear receptor family of transcription factors (Yuan, 1998). It was later determined that many of the components of the TRAP complex are also in the DRIP complex, and in the ARC complex.

The TRAP complex contains the following 14 proteins, which also are common to the DRIP and ARC complexes: MED1, MED4, MED6, MED7, MED10, MED12, MED13, MED14, MED16, MED17, MED23, MED24, CDK8, CycC.

The TRAP complex also contains 4 additional components, which are now called: MED20, MED27, MED30, and MED 31 in the unified nomenclature scheme (Bourbon, 2004).

In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator complex proteins in yeast, first identified by Kornberg and colleagues (Kelleher, 1990). The unified nomenclature system for these adapter / co-activator proteins now labels them Mediator 1 through Mediator 31 (Bourbon, 2004).

The order of addition of the TRAP proteins during complex assembly is not fully determined, and may vary in different cell contexts. Therefore, TRAP co-activator complex assembly is represented as a single reaction event, in which all 18 components assemble simultaneously into the TRAP co-activator complex.

Pubmed10235266

Pubmed2163759

Pubmed9653119

Reactome, http://www.reactome.org

Pubmed15175151

Pubmed9637681

http://purl.obolibrary.org/obo/UniProt_Q93074

http://purl.obolibrary.org/obo/HINO_0016201

http://purl.obolibrary.org/obo/HINO_0016208

http://purl.obolibrary.org/obo/UniProt_Q96HR3

http://purl.obolibrary.org/obo/UniProt_Q9UHV7

http://purl.obolibrary.org/obo/UniProt_O43513

http://purl.obolibrary.org/obo/UniProt_Q15648

http://purl.obolibrary.org/obo/HINO_0016167

http://purl.obolibrary.org/obo/UniProt_Q9BTT4

http://purl.obolibrary.org/obo/UniProt_Q9NVC6

http://purl.obolibrary.org/obo/UniProt_O75448

http://purl.obolibrary.org/obo/UniProt_O60244

http://purl.obolibrary.org/obo/UniProt_Q9H944

http://purl.obolibrary.org/obo/UniProt_P49336

http://purl.obolibrary.org/obo/UniProt_P24863

http://purl.obolibrary.org/obo/UniProt_Q9Y3C7

http://purl.obolibrary.org/obo/UniProt_O75586

http://purl.obolibrary.org/obo/UniProt_Q9NPJ6

http://purl.obolibrary.org/obo/HINO_0012098

Formation of TRAP coactivator complex

HINO:0019780

Formation of TRAP coactivator complex

Reactome Database ID Release 43212380

ReactomeREACT_12410

http://purl.obolibrary.org/obo/INO_0000040