Reviewed: Freedman, LP, 2008-02-25 20:35:15 DRIP co-activator complex and assembly<br><br>The DRIP co-activator complex is a subset of 14 proteins from the set of at least 31 Mediator proteins that, in different combinations, form "Adapter" complexes. Adapter complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (reviewed in Maston, 2006 and Naar, 2001).<br><br>The DRIP complex was originally identified and named as a co-activator complex associated with the Vitamin D Receptor member of the nuclear receptor family of transcription factors (Rachez, 1998). It was later determined that all of the components of the DRIP complex were also in the TRAP complex, and the ARC complex.<br><br>The DRIP complex contains the following 14 proteins, which also are common to the ARC and TRAP complexes: MED1, MED4, MED6, MED7, MED10, MED12, MED13, MED14, MED16, MED17, MED23, MED24, CDK8, CycC. <br><br>All of the DRIP adapter complex components are present in the ARC adapter complex, but the ARC complex also has 4 additional components (Rachez, 1999). These ARC-specific components are now called: MED8, MED15, MED25, and MED 26 in the unified nomenclature scheme (Bourbon, 2004).<br><br>Similarly, all 14 of the DRIP adapter complex components are present in the TRAP adapter complex, but the TRAP complex also has 4 additional components (Bourbon, 2004), These TRAP-specific components are now called: MED20, MED27, MED30, and MED 31 in the unified nomenclature scheme.<br><br>In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator complex identified in yeast, first identified by Kornberg and colleagues (Kelleher, 1990).<br><br>

http://purl.obolibrary.org/obo/HINO_0019779

Reviewed: Freedman, LP, 2008-02-25 20:35:15

DRIP co-activator complex and assembly

The DRIP co-activator complex is a subset of 14 proteins from the set of at least 31 Mediator proteins that, in different combinations, form "Adapter" complexes. Adapter complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (reviewed in Maston, 2006 and Naar, 2001).

The DRIP complex was originally identified and named as a co-activator complex associated with the Vitamin D Receptor member of the nuclear receptor family of transcription factors (Rachez, 1998). It was later determined that all of the components of the DRIP complex were also in the TRAP complex, and the ARC complex.

The DRIP complex contains the following 14 proteins, which also are common to the ARC and TRAP complexes: MED1, MED4, MED6, MED7, MED10, MED12, MED13, MED14, MED16, MED17, MED23, MED24, CDK8, CycC.

All of the DRIP adapter complex components are present in the ARC adapter complex, but the ARC complex also has 4 additional components (Rachez, 1999). These ARC-specific components are now called: MED8, MED15, MED25, and MED 26 in the unified nomenclature scheme (Bourbon, 2004).

Similarly, all 14 of the DRIP adapter complex components are present in the TRAP adapter complex, but the TRAP complex also has 4 additional components (Bourbon, 2004), These TRAP-specific components are now called: MED20, MED27, MED30, and MED 31 in the unified nomenclature scheme.

In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator complex identified in yeast, first identified by Kornberg and colleagues (Kelleher, 1990).

Pubmed10235266

Pubmed2163759

Pubmed16719718

Pubmed11395415

Pubmed9653119

Reactome, http://www.reactome.org

Pubmed15175151

Pubmed9637681

http://purl.obolibrary.org/obo/UniProt_Q93074

http://purl.obolibrary.org/obo/HINO_0016208

http://purl.obolibrary.org/obo/UniProt_Q9UHV7

http://purl.obolibrary.org/obo/UniProt_O43513

http://purl.obolibrary.org/obo/UniProt_Q15648

http://purl.obolibrary.org/obo/HINO_0016167

http://purl.obolibrary.org/obo/UniProt_Q9BTT4

http://purl.obolibrary.org/obo/UniProt_Q9NVC6

http://purl.obolibrary.org/obo/UniProt_O75448

http://purl.obolibrary.org/obo/UniProt_O60244

http://purl.obolibrary.org/obo/UniProt_P49336

http://purl.obolibrary.org/obo/UniProt_P24863

http://purl.obolibrary.org/obo/UniProt_O75586

http://purl.obolibrary.org/obo/UniProt_Q9NPJ6

http://purl.obolibrary.org/obo/HINO_0012100

Formation of DRIP coactivator complex

HINO:0019779

Formation of DRIP coactivator complex

ReactomeREACT_12379

Reactome Database ID Release 43212432

http://purl.obolibrary.org/obo/INO_0000040