Reviewed: Freedman, LP, 2008-02-25 20:35:15 ARC co-activator complex and assembly<br><br>The ARC co-activator complex is a subset of 18 proteins from the set of at least 31 Mediator proteins that, in different combinations, form "Adapter" complexes in human cells. Adapter complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (reviewed in Maston, 2006 and Naar, 2001).<br><br>The ARC complex was originally identified and named as a co-activator complex associated with transcription activator proteins (reviewed in Malik, 2005 and references therein). It was subsequently determined that many of the components of the ARC complex are also in the DRIP complex, and in the TRAP complex..<br><br>The ARC complex contains the following 14 proteins, which also are common to the DRIP and TRAP complexes: MED1, MED4, MED6, MED7, MED10, MED12, MED13, MED14, MED16, MED17, MED23, MED24, CDK8, CycC. <br><br>The ARC complex also contains 4 additional, ARC-specific components, which are now called: MED8, MED15, MED25, and MED 26 in the unified nomenclature scheme (Bourbon, 2004).<br><br>In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator complex proteins in yeast, first identified by Kornberg and colleagues (Kelleher, 1990). The unified nomenclature system for these adapter / co-activator proteins now labels them Mediator 1 through Mediator 31 (Bourbon, 2004).<br><br>The order of addition of the ARC proteins during complex assembly is not fully determined, and may vary in different cell contexts. Therefore, ARC complex assembly is represented as a single reaction event, in which all 19 components assemble simultaneously into the ARC co-activator complex.<br><br>

http://purl.obolibrary.org/obo/HINO_0019777

Reviewed: Freedman, LP, 2008-02-25 20:35:15

ARC co-activator complex and assembly

The ARC co-activator complex is a subset of 18 proteins from the set of at least 31 Mediator proteins that, in different combinations, form "Adapter" complexes in human cells. Adapter complexes bridge between the basal transcription factors (including Pol II) and tissue-specific transcription factors (TFs) bound to sites within upstream Proximal Promoter regions or distal Enhancer regions (reviewed in Maston, 2006 and Naar, 2001).

The ARC complex was originally identified and named as a co-activator complex associated with transcription activator proteins (reviewed in Malik, 2005 and references therein). It was subsequently determined that many of the components of the ARC complex are also in the DRIP complex, and in the TRAP complex..

The ARC complex contains the following 14 proteins, which also are common to the DRIP and TRAP complexes: MED1, MED4, MED6, MED7, MED10, MED12, MED13, MED14, MED16, MED17, MED23, MED24, CDK8, CycC.

The ARC complex also contains 4 additional, ARC-specific components, which are now called: MED8, MED15, MED25, and MED 26 in the unified nomenclature scheme (Bourbon, 2004).

In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator complex proteins in yeast, first identified by Kornberg and colleagues (Kelleher, 1990). The unified nomenclature system for these adapter / co-activator proteins now labels them Mediator 1 through Mediator 31 (Bourbon, 2004).

The order of addition of the ARC proteins during complex assembly is not fully determined, and may vary in different cell contexts. Therefore, ARC complex assembly is represented as a single reaction event, in which all 19 components assemble simultaneously into the ARC co-activator complex.

Pubmed10235266

Pubmed2163759

Pubmed16719718

Pubmed9653119

Reactome, http://www.reactome.org

Pubmed15175151

Pubmed9637681

Pubmed15896744

http://purl.obolibrary.org/obo/UniProt_Q71SY5

http://purl.obolibrary.org/obo/UniProt_Q93074

http://purl.obolibrary.org/obo/HINO_0016208

http://purl.obolibrary.org/obo/HINO_0016209

http://purl.obolibrary.org/obo/HINO_0016206

http://purl.obolibrary.org/obo/UniProt_Q9UHV7

http://purl.obolibrary.org/obo/UniProt_O43513

http://purl.obolibrary.org/obo/UniProt_Q15648

http://purl.obolibrary.org/obo/HINO_0016167

http://purl.obolibrary.org/obo/UniProt_Q9BTT4

http://purl.obolibrary.org/obo/UniProt_Q9NVC6

http://purl.obolibrary.org/obo/UniProt_O75448

http://purl.obolibrary.org/obo/UniProt_O60244

http://purl.obolibrary.org/obo/UniProt_P49336

http://purl.obolibrary.org/obo/HINO_0016211

http://purl.obolibrary.org/obo/UniProt_P24863

http://purl.obolibrary.org/obo/UniProt_O75586

http://purl.obolibrary.org/obo/UniProt_Q9NPJ6

http://purl.obolibrary.org/obo/HINO_0012102

Formation of ARC coactivator complex

HINO:0019777

Formation of ARC coactivator complex

ReactomeREACT_12480

Reactome Database ID Release 43212352

http://purl.obolibrary.org/obo/INO_0000040