loading...| Preferred Name | Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane | |
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Authored: D'Eustachio, P, 2007-06-22 14:17:01 Edited: D'Eustachio, P, 2008-09-12 22:05:52 Reviewed: Harris, RA, 2008-09-10 18:47:12 The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate and cytosolic alpha-ketoglutarate (2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from stdies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996). |
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http://purl.obolibrary.org/obo/HINO_0019631 |
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Authored: D'Eustachio, P, 2007-06-22 14:17:01 Edited: D'Eustachio, P, 2008-09-12 22:05:52 Reviewed: Harris, RA, 2008-09-10 18:47:12 The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate and cytosolic alpha-ketoglutarate (2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from stdies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996). |
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| definition source |
Reactome, http://www.reactome.org Pubmed8597574 Pubmed4687397 Pubmed16920706 |
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Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane |
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malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] |
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| prefixIRI |
HINO:0019631 |
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| prefLabel |
Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane |
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ReactomeREACT_11181 Reactome Database ID Release 43198440 |
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