Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
Synonyms
Definitions

The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995). Reviewed: Harris, RA, 2008-09-10 18:47:12

ID

http://purl.obolibrary.org/obo/HINO_0019354

comment

The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995).

Reviewed: Harris, RA, 2008-09-10 18:47:12

definition source

Reactome, http://www.reactome.org

Pubmed7574501

has input

http://purl.obolibrary.org/obo/CHEBI_15377

http://purl.obolibrary.org/obo/CHEBI_28602

has output

http://purl.obolibrary.org/obo/CHEBI_18367

http://purl.obolibrary.org/obo/CHEBI_15946

label

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate

prefixIRI

HINO:0019354

prefLabel

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate

seeAlso

Reactome Database ID Release 4370262

ReactomeREACT_1084

EC Number: 3.1.3.46

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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