Link to this page
Human Interaction Network Ontology
| Preferred Name | Interaction of E3 with substrate and E2-Ub complex | |
| Synonyms |
|
|
| Definitions |
Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0018270 |
|
| comment |
Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
|
|
| definition source |
Reactome, http://www.reactome.org Pubmed16954532 Pubmed19489725 Pubmed12646216
|
|
| has input |
http://purl.obolibrary.org/obo/HINO_0009678 |
|
| has output | ||
| label |
Interaction of E3 with substrate and E2-Ub complex
|
|
| prefixIRI |
HINO:0018270
|
|
| prefLabel |
Interaction of E3 with substrate and E2-Ub complex
|
|
| seeAlso |
ReactomeREACT_75856 Reactome Database ID Release 43983157
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |