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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Transfer of Ub from E2 to substrate and release of E2 | |
| Synonyms |
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| Definitions |
Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009). Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018268 |
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| comment |
Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009). Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29
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| definition source |
Reactome, http://www.reactome.org Pubmed16954532 Pubmed19489725 Pubmed12646216
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| has output |
http://purl.obolibrary.org/obo/CHEBI_29888 http://purl.obolibrary.org/obo/HINO_0009849 |
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| label |
Transfer of Ub from E2 to substrate and release of E2
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| prefixIRI |
HINO:0018268
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| prefLabel |
Transfer of Ub from E2 to substrate and release of E2
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| seeAlso |
Reactome Database ID Release 43983140 EC Number: 6.3.2.19 ReactomeREACT_75901
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