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Human Interaction Network Ontology
| Preferred Name | Binding of newly synthesized MHC class I heavy chain (HC) with calnexin | |
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| Definitions |
Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation. Edited: Garapati, P V, 2010-10-29 |
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http://purl.obolibrary.org/obo/HINO_0018264 |
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| comment |
Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation. Edited: Garapati, P V, 2010-10-29
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| definition source |
Pubmed12495737 Reactome, http://www.reactome.org Pubmed11160214 Pubmed10777614 Pubmed7876241 Pubmed7642652 Pubmed11470776 Pubmed11514579 Pubmed9605141
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Binding of newly synthesized MHC class I heavy chain (HC) with calnexin
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| prefixIRI |
HINO:0018264
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| prefLabel |
Binding of newly synthesized MHC class I heavy chain (HC) with calnexin
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| seeAlso |
ReactomeREACT_75754 Reactome Database ID Release 43983145
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