loading...| Preferred Name | Formation of peptide loading complex (PLC) | |
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| Definitions |
Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptorâassociated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018230 |
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| comment |
Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptorâassociated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| definition source |
Pubmed19426129 Pubmed19361863 Pubmed15286279 Reactome, http://www.reactome.org Pubmed14718384 Pubmed16465444 Pubmed19119025 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0005638 http://purl.obolibrary.org/obo/HINO_0004328 http://purl.obolibrary.org/obo/UniProt_O15533 |
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| label |
Formation of peptide loading complex (PLC) |
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| prefixIRI |
HINO:0018230 |
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| prefLabel |
Formation of peptide loading complex (PLC) |
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| seeAlso |
Reactome Database ID Release 43983142 ReactomeREACT_75922 |
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