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Human Interaction Network Ontology
| Preferred Name | Peptide loading on MHC class I in phagosome | |
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| Definitions |
Authored: Garapati, P V, 2011-03-28 Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen. Edited: Garapati, P V, 2011-03-28 Reviewed: Desjardins, M, English, L, 2011-05-13 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018205 |
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| comment |
Authored: Garapati, P V, 2011-03-28 Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen. Edited: Garapati, P V, 2011-03-28 Reviewed: Desjardins, M, English, L, 2011-05-13
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| definition source |
Pubmed14508490 Reactome, http://www.reactome.org Pubmed14508489
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| has output |
http://purl.obolibrary.org/obo/HINO_0004377 http://purl.obolibrary.org/obo/UniProt_P30101 |
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| label |
Peptide loading on MHC class I in phagosome
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| prefixIRI |
HINO:0018205
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| prefLabel |
Peptide loading on MHC class I in phagosome
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| seeAlso |
Reactome Database ID Release 431236971 ReactomeREACT_111153
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