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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0018196
http://purl.obolibrary.org/obo/HINO_0018196
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|---|---|
| Preferred Name | Interaction of particulate antigens with dendritic cell receptors |
| Definitions |
Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
Authored: Garapati, P V, 2011-03-28
Edited: Garapati, P V, 2011-03-28
Reviewed: Desjardins, M, English, L, 2011-05-13
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Interaction of particulate antigens with dendritic cell receptors
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| comment |
Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
Authored: Garapati, P V, 2011-03-28
Edited: Garapati, P V, 2011-03-28
Reviewed: Desjardins, M, English, L, 2011-05-13
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| prefLabel |
Interaction of particulate antigens with dendritic cell receptors
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| definition source |
Pubmed7678924
Pubmed9523111
Reactome, http://www.reactome.org
Pubmed8901603
Pubmed18331591
Pubmed1383273
Pubmed9763615
Pubmed1688647
Pubmed18268517
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| prefixIRI |
HINO:0018196
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| seeAlso |
Reactome Database ID Release 431236958
ReactomeREACT_111137
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| subClassOf | |
| type | |
| has input | |
| has output |
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