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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Capturing cargo and formation of prebudding complex | |
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| Definitions |
The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018171 |
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| comment |
The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29
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| definition source |
Pubmed10825291 Pubmed17316621 Pubmed11163199 Reactome, http://www.reactome.org Pubmed10982397
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| label |
Capturing cargo and formation of prebudding complex
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| prefixIRI |
HINO:0018171
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| prefLabel |
Capturing cargo and formation of prebudding complex
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| seeAlso |
ReactomeREACT_75836 Reactome Database ID Release 43983426
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