loading...| Preferred Name | Transport of Antigen peptide in to ER | |
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| Definitions |
has a Stoichiometric coefficient of 2 Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018167 |
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| comment |
has a Stoichiometric coefficient of 2 Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| definition source |
Reactome, http://www.reactome.org Pubmed8342042 Pubmed12645939 Pubmed19261456 Pubmed10600378 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0005642 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_18367 |
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| label |
Transport of Antigen peptide in to ER |
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| prefixIRI |
HINO:0018167 |
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| prefLabel |
Transport of Antigen peptide in to ER |
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| seeAlso |
ReactomeREACT_75812 Reactome Database ID Release 43983144 |
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| subClassOf |