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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Trimming of peptides in ER | |
| Synonyms |
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| Definitions |
Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018166 |
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| comment |
Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29
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| definition source |
Reactome, http://www.reactome.org Pubmed12436109 Pubmed17088086 Pubmed12436110
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| has input | ||
| has output | ||
| label |
Trimming of peptides in ER
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| prefixIRI |
HINO:0018166
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| prefLabel |
Trimming of peptides in ER
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| seeAlso |
ReactomeREACT_75798 Reactome Database ID Release 43983158
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| subClassOf |
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