Human Interaction Network Ontology

Last uploaded: June 27, 2014
Jump to:
Id http://purl.obolibrary.org/obo/HINO_0018141
http://purl.obolibrary.org/obo/HINO_0018141
Preferred Name

Egress of internalized antigen into cytosol from early endosome
Definitions
Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism. <br>There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).<br>Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen. Authored: Garapati, P V, 2011-03-28 Edited: Garapati, P V, 2011-03-28 Reviewed: Desjardins, M, English, L, 2011-05-13
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Egress of internalized antigen into cytosol from early endosome
comment
Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism. <br>There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).<br>Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen.
Authored: Garapati, P V, 2011-03-28
Edited: Garapati, P V, 2011-03-28
Reviewed: Desjardins, M, English, L, 2011-05-13
prefLabel
Egress of internalized antigen into cytosol from early endosome
definition source
Pubmed9022030
Pubmed18425099
Pubmed16818754
Reactome, http://www.reactome.org
Pubmed8752913
Pubmed18376402
Pubmed17157489
Pubmed20171863
Pubmed15020715
Pubmed16530046
Pubmed15744304
Pubmed10559964
Pubmed15761154
Pubmed15592474
Pubmed9257826
See more
See less
prefixIRI
HINO:0018141
seeAlso
ReactomeREACT_111203
Reactome Database ID Release 431236968
subClassOf
type
has input
has output
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display