MHC class II epitopes require protein denaturation and removal of intra- and inter-chain disulphide bonds prior to proteolysis. The lysosomal thiol reductase gamma-IFN-inducible lysosomal thiol reductase (GILT) has been shown to facilitate MHC class II-restricted antigen (Ag) processing by breaking disulphide bonds. GILT is constitutively expressed in APCs. The reduction of disulphide bonds by mature GILT is optimal at acidic pH (Hastings et al. 2006, Arunachalam et al. 2000). Authored: Garapati, P V, 2012-02-21 Edited: Garapati, P V, 2012-02-21 Reviewed: Neefjes, Jacques, 2012-05-14

http://purl.obolibrary.org/obo/HINO_0018132

MHC class II epitopes require protein denaturation and removal of intra- and inter-chain disulphide bonds prior to proteolysis. The lysosomal thiol reductase gamma-IFN-inducible lysosomal thiol reductase (GILT) has been shown to facilitate MHC class II-restricted antigen (Ag) processing by breaking disulphide bonds. GILT is constitutively expressed in APCs. The reduction of disulphide bonds by mature GILT is optimal at acidic pH (Hastings et al. 2006, Arunachalam et al. 2000).

Authored: Garapati, P V, 2012-02-21

Edited: Garapati, P V, 2012-02-21

Reviewed: Neefjes, Jacques, 2012-05-14

Pubmed17142755

Reactome, http://www.reactome.org

Pubmed10639150

http://purl.obolibrary.org/obo/HINO_0005683

http://purl.obolibrary.org/obo/HINO_0005682

Reduction of disulphide bonds in MHC II antigens

HINO:0018132

Reduction of disulphide bonds in MHC II antigens

EC Number: 1.8

Reactome Database ID Release 432213240

ReactomeREACT_121326

http://purl.obolibrary.org/obo/INO_0000040