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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0018129
http://purl.obolibrary.org/obo/HINO_0018129
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|---|---|
| Preferred Name | Generation of CLIP from lip10 |
| Definitions |
The lip10 fragments bound in the nonameric complex are processed leaving only the CLIP fragment (81-105) bound to the MHC II peptide binding groove. Three cysteine proteases have been shown to be capable of digesting lip10, each with a different expression pattern among different APC. Cathepsin (Cat) S digests Ii in B cells and dendritic cells, thymic epithelial cells use Cat L and Cat L, while Cat S and F are active in macrophages (Villadangos, 2001; Bryant et al, 2002). Cat S appears to be the major enzyme involved as demonstrated by the use of specific inhibitors and of knockout experiments (Stumptner-Cuvelette et al. 2002). Following lip10 digestion, the MHC-like molecule HLA-DM induces the exchange of CLIP fragment for a highly diverse array of antigens (Denzin & Cresswell. 1995).
Authored: Garapati, P V, 2012-02-21
Edited: Garapati, P V, 2012-02-21
has a Stoichiometric coefficient of 3
Reviewed: Neefjes, Jacques, 2012-05-14
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Generation of CLIP from lip10
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|---|---|
| comment |
The lip10 fragments bound in the nonameric complex are processed leaving only the CLIP fragment (81-105) bound to the MHC II peptide binding groove. Three cysteine proteases have been shown to be capable of digesting lip10, each with a different expression pattern among different APC. Cathepsin (Cat) S digests Ii in B cells and dendritic cells, thymic epithelial cells use Cat L and Cat L, while Cat S and F are active in macrophages (Villadangos, 2001; Bryant et al, 2002). Cat S appears to be the major enzyme involved as demonstrated by the use of specific inhibitors and of knockout experiments (Stumptner-Cuvelette et al. 2002). Following lip10 digestion, the MHC-like molecule HLA-DM induces the exchange of CLIP fragment for a highly diverse array of antigens (Denzin & Cresswell. 1995).
Authored: Garapati, P V, 2012-02-21
Edited: Garapati, P V, 2012-02-21
has a Stoichiometric coefficient of 3
Reviewed: Neefjes, Jacques, 2012-05-14
|
| prefLabel |
Generation of CLIP from lip10
|
| definition source |
Pubmed12748383
Pubmed10748235
Reactome, http://www.reactome.org
Pubmed11853874
Pubmed10072072
Pubmed11684289
Pubmed9545226
Pubmed12078484
Pubmed7606781
Pubmed10631941
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| prefixIRI |
HINO:0018129
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| seeAlso |
ReactomeREACT_121107
Reactome Database ID Release 432130349
EC Number: 3.4.22
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| subClassOf | |
| type | |
| has input | |
| has output |
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