loading...| Preferred Name | Trafficking of nonameric complex in the endocytic pathway | |
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| Definitions |
The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009). Authored: Garapati, P V, 2012-02-21 Edited: Garapati, P V, 2012-02-21 Reviewed: Neefjes, Jacques, 2012-05-14 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018127 |
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| comment |
The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009). Authored: Garapati, P V, 2012-02-21 Edited: Garapati, P V, 2012-02-21 Reviewed: Neefjes, Jacques, 2012-05-14 |
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| definition source |
Pubmed19703008 Reactome, http://www.reactome.org Pubmed14731593 |
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| label |
Trafficking of nonameric complex in the endocytic pathway |
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| prefixIRI |
HINO:0018127 |
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| prefLabel |
Trafficking of nonameric complex in the endocytic pathway |
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| seeAlso |
Reactome Database ID Release 432213235 ReactomeREACT_120768 |
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