loading...| Preferred Name | TLR folding by chaperones GP96 and CNPY3 | |
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| Definitions |
has a Stoichiometric coefficient of 2 Edited: Shamovsky, V, 2012-02-19 Reviewed: Leifer, CA, Rose II, WA, 2012-02-28 GP96 (also known as GRP94, HSP90b1), a paralogue of HSP90 in the endoplasmic reticulum, acts as a chaperone for some integrines and Toll-like receptors. Macrophages or B-cells from gp96 knockout mice have abrogated function of TLR2, 4, 5, 7 and 9, but not TLR3 (Yang Y et al 2007, Liu B and Li Z 2008, Staron M et al 2010). GP96 interacts with TLRs and integrines via its C-terminal hydrophobic domain, formed by residues 652-678 (Wu S et al 2012). GP96 functions as a V-shaped dimer in ATP-dependent manner, however it remains unclear how ATP hydrolysis-dependent conformational changes of GP96 are regulated (Li Z and Srivastava PK 1993).<p>GP96 forms a complex with co-chaperone CNPY3, also known as PRAT4A. GP96-CNPY3 promotes the proper post-translational ectodomain folding of TLRs, but not TLR3 (Liu B et al 2010). Reviewed: Gillespie, ME, 2012-02-09 Authored: Shamovsky, V, 2011-10-19 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0018093 |
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| comment |
has a Stoichiometric coefficient of 2 Edited: Shamovsky, V, 2012-02-19 Reviewed: Leifer, CA, Rose II, WA, 2012-02-28 GP96 (also known as GRP94, HSP90b1), a paralogue of HSP90 in the endoplasmic reticulum, acts as a chaperone for some integrines and Toll-like receptors. Macrophages or B-cells from gp96 knockout mice have abrogated function of TLR2, 4, 5, 7 and 9, but not TLR3 (Yang Y et al 2007, Liu B and Li Z 2008, Staron M et al 2010). GP96 interacts with TLRs and integrines via its C-terminal hydrophobic domain, formed by residues 652-678 (Wu S et al 2012). GP96 functions as a V-shaped dimer in ATP-dependent manner, however it remains unclear how ATP hydrolysis-dependent conformational changes of GP96 are regulated (Li Z and Srivastava PK 1993). GP96 forms a complex with co-chaperone CNPY3, also known as PRAT4A. GP96-CNPY3 promotes the proper post-translational ectodomain folding of TLRs, but not TLR3 (Liu B et al 2010). Reviewed: Gillespie, ME, 2012-02-09 Authored: Shamovsky, V, 2011-10-19 |
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| definition source |
Pubmed22223641 Pubmed18509083 Reactome, http://www.reactome.org Pubmed8344253 Pubmed19965672 Pubmed20865800 Pubmed17275357 |
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| has input |
http://purl.obolibrary.org/obo/UniProt_Q9BT09 http://purl.obolibrary.org/obo/HINO_0004183 |
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| label |
TLR folding by chaperones GP96 and CNPY3 |
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| prefixIRI |
HINO:0018093 |
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| prefLabel |
TLR folding by chaperones GP96 and CNPY3 |
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| seeAlso |
ReactomeREACT_118729 Reactome Database ID Release 431678923 |
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