Human Interaction Network Ontology

Last uploaded: June 27, 2014
Jump to:
Id http://purl.obolibrary.org/obo/HINO_0018089
http://purl.obolibrary.org/obo/HINO_0018089
Preferred Name

UNC93B1 delivers endosomal full-length TLRs to endolysosome
Definitions
TLR3, 7, 8 and 9 activation occurs within acidified endolysosomal compartments. Inhibition of endosome acidification with bafilomicin A or chloroquine abrogated TLR's-mediated responses to pathogen-derived nucleic acids (Hacker H et al 1998, Funami K et al 2004, Gibbard RJ et al 2006, Kuznik A et al 2011). Upon stimulation, TLR3, 7, and 9 (and possibly TLR8) are transported to the signaling endosomes by UNC93B1, whereby they become functional receptors and bind to their specific ligands (Kim et al 2008, Ewald et al 2011). Although UNC93B1 is critically involved in TLRs trafficking it was dispensable for ligand binding by these TLRs (Kim YM et al 2008). Edited: Shamovsky, V, 2012-02-19 Reviewed: Leifer, CA, Rose II, WA, 2012-02-28 Reviewed: Gillespie, ME, 2012-02-09 Authored: Shamovsky, V, 2011-10-19
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
UNC93B1 delivers endosomal full-length TLRs to endolysosome
comment
TLR3, 7, 8 and 9 activation occurs within acidified endolysosomal compartments. Inhibition of endosome acidification with bafilomicin A or chloroquine abrogated TLR's-mediated responses to pathogen-derived nucleic acids (Hacker H et al 1998, Funami K et al 2004, Gibbard RJ et al 2006, Kuznik A et al 2011). Upon stimulation, TLR3, 7, and 9 (and possibly TLR8) are transported to the signaling endosomes by UNC93B1, whereby they become functional receptors and bind to their specific ligands (Kim et al 2008, Ewald et al 2011). Although UNC93B1 is critically involved in TLRs trafficking it was dispensable for ligand binding by these TLRs (Kim YM et al 2008).
Edited: Shamovsky, V, 2012-02-19
Reviewed: Leifer, CA, Rose II, WA, 2012-02-28
Reviewed: Gillespie, ME, 2012-02-09
Authored: Shamovsky, V, 2011-10-19
prefLabel
UNC93B1 delivers endosomal full-length TLRs to endolysosome
definition source
Pubmed9799232
Pubmed15226270
Pubmed21402738
Reactome, http://www.reactome.org
Pubmed14716310
Pubmed16857668
Pubmed21398612
Pubmed18305481
See more
See less
prefixIRI
HINO:0018089
seeAlso
Reactome Database ID Release 431678927
ReactomeREACT_118774
subClassOf
type
has input
has output
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display