loading...| Preferred Name | TLR9 processing at neutral pH | |
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Edited: Shamovsky, V, 2012-02-19 Reviewed: Leifer, CA, Rose II, WA, 2012-02-28 Reviewed: Gillespie, ME, 2012-02-09 Authored: Shamovsky, V, 2011-10-19 TLR9 traffics to an endosomal vesicle where it is processed by cathepsin S at neural pH to generate an N-terminal product (TLR9 N-ter, aa 1-723). The N-terminal fragment of TLR9 also binds ligand, but in contrast to the C-terminal fragment it inhibits TLR9 signaling. Thus, a proper balance between the two proteolytic events probably regulates TLR9-mediated host responses. (Chockalingam A et al 2011). |
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http://purl.obolibrary.org/obo/HINO_0018085 |
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Edited: Shamovsky, V, 2012-02-19 Reviewed: Leifer, CA, Rose II, WA, 2012-02-28 Reviewed: Gillespie, ME, 2012-02-09 Authored: Shamovsky, V, 2011-10-19 TLR9 traffics to an endosomal vesicle where it is processed by cathepsin S at neural pH to generate an N-terminal product (TLR9 N-ter, aa 1-723). The N-terminal fragment of TLR9 also binds ligand, but in contrast to the C-terminal fragment it inhibits TLR9 signaling. Thus, a proper balance between the two proteolytic events probably regulates TLR9-mediated host responses. (Chockalingam A et al 2011). |
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| definition source |
Reactome, http://www.reactome.org Pubmed21604257 |
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| label |
TLR9 processing at neutral pH |
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HINO:0018085 |
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TLR9 processing at neutral pH |
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Reactome Database ID Release 431678981 ReactomeREACT_118693 EC Number: 3.4.22 |
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