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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0017851
http://purl.obolibrary.org/obo/HINO_0017851
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| Preferred Name | Recruitment of PI3K to plasmamembrane |
| Definitions |
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
In response to the TCR stimulation, phsophoinositides are phosphorylated on the 3-position of the inositol ring by PI3K to generate lipid second messengers that serve as membrane docking sites for a variety of downstream effector proteins such as PDK1 and PKB. PI3K is a heterodimer comprising a regulatory subunit p85 and a catalytic subunit p110 which associate constitutively and are activated upon interaction with tyrosine-phosphorylated proteins at the plasma membrane. The p85 subunit contains two SH2 domains and an SH3 domain. p85 subunit is involved in interaction with two phsophotyrosine residues of the adaptor protein TRIM with its two SH2 domains. This interaction is important in recruiting the p110 subunit to the plasma membrane and activate the p110 kinase activity, which is normally inhibited in the p85-p110 complex.
Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Recruitment of PI3K to plasmamembrane
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| comment |
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
In response to the TCR stimulation, phsophoinositides are phosphorylated on the 3-position of the inositol ring by PI3K to generate lipid second messengers that serve as membrane docking sites for a variety of downstream effector proteins such as PDK1 and PKB. PI3K is a heterodimer comprising a regulatory subunit p85 and a catalytic subunit p110 which associate constitutively and are activated upon interaction with tyrosine-phosphorylated proteins at the plasma membrane. The p85 subunit contains two SH2 domains and an SH3 domain. p85 subunit is involved in interaction with two phsophotyrosine residues of the adaptor protein TRIM with its two SH2 domains. This interaction is important in recruiting the p110 subunit to the plasma membrane and activate the p110 kinase activity, which is normally inhibited in the p85-p110 complex.
Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| prefLabel |
Recruitment of PI3K to plasmamembrane
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| definition source |
Pubmed12660731
Reactome, http://www.reactome.org
Pubmed16612002
Pubmed9687533
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| prefixIRI |
HINO:0017851
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| seeAlso |
ReactomeREACT_12486
Reactome Database ID Release 43202203
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| subClassOf | |
| type | |
| has input | |
| has output |
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