loading...| Preferred Name | PLC-gamma1 hydrolyses PIP2 | |
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| Definitions |
Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017841 |
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| comment |
Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation. |
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| definition source |
Reactome, http://www.reactome.org |
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| label |
PLC-gamma1 hydrolyses PIP2 |
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| prefixIRI |
HINO:0017841 |
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| prefLabel |
PLC-gamma1 hydrolyses PIP2 |
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| seeAlso |
ReactomeREACT_12585 Reactome Database ID Release 43202407 EC Number: 3.1.4.11 |
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