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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Phosphorylation of ITAM motifs in CD3 complexes | |
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| Definitions |
The autophosphorylated, active Lck is now proximally positioned to phosphorylate specific tyrosine residues within ITAMs (immunoreceptor tyrosine-based activation motifs) located within the CD3 and the TCR zeta signaling chains of the TCR. ITAMs consist of evolutionarily conserved amino-acid sequence motifs of D/ExYxxLx(6-8)YxxL. Both the tyrosine residues in the motif are phosphorylated by Lck and the TCR complex include 10 ITAMs with one ITAM in each of the CD3 chains including the three tandem ITAMs in each zeta chains. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 has a Stoichiometric coefficient of 20 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017823 |
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| comment |
The autophosphorylated, active Lck is now proximally positioned to phosphorylate specific tyrosine residues within ITAMs (immunoreceptor tyrosine-based activation motifs) located within the CD3 and the TCR zeta signaling chains of the TCR. ITAMs consist of evolutionarily conserved amino-acid sequence motifs of D/ExYxxLx(6-8)YxxL. Both the tyrosine residues in the motif are phosphorylated by Lck and the TCR complex include 10 ITAMs with one ITAM in each of the CD3 chains including the three tandem ITAMs in each zeta chains. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 has a Stoichiometric coefficient of 20 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| definition source |
Reactome, http://www.reactome.org Pubmed16364187 Pubmed15084594
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| label |
Phosphorylation of ITAM motifs in CD3 complexes
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| prefixIRI |
HINO:0017823
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| prefLabel |
Phosphorylation of ITAM motifs in CD3 complexes
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| seeAlso |
Reactome Database ID Release 43202165 EC Number: 2.7.10 ReactomeREACT_12633
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