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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Dephosphorylation of Lck-pY505 by CD45 | |
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| Definitions |
TCR stimulation induce the transient dephosphorylation of PAG thereby release the Csk from its plasma membrane anchor. The release of Csk from its proximity with Lck may serve to facilitate the activation of Lck. The inactive Lck is dephosphorylated by CD45 phosphatase. CD45 specifically dephosphorylates the Y505 residue of Lck and induce the active open conformation. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017821 |
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| comment |
TCR stimulation induce the transient dephosphorylation of PAG thereby release the Csk from its plasma membrane anchor. The release of Csk from its proximity with Lck may serve to facilitate the activation of Lck. The inactive Lck is dephosphorylated by CD45 phosphatase. CD45 specifically dephosphorylates the Y505 residue of Lck and induce the active open conformation. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| definition source |
Pubmed11827988 Reactome, http://www.reactome.org
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| label |
Dephosphorylation of Lck-pY505 by CD45
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| prefixIRI |
HINO:0017821
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| prefLabel |
Dephosphorylation of Lck-pY505 by CD45
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| seeAlso |
Reactome Database ID Release 43202214 ReactomeREACT_12446 EC Number: 3.1.3.48
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