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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Activation of Lck | |
| Synonyms |
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| Definitions |
The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017820 |
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| comment |
The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
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| definition source |
Pubmed11827988 Reactome, http://www.reactome.org Pubmed15489916
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| label |
Activation of Lck
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| prefixIRI |
HINO:0017820
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| prefLabel |
Activation of Lck
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| seeAlso |
ReactomeREACT_12467 EC Number: 2.7.10 Reactome Database ID Release 43202291
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