Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0017819
http://purl.obolibrary.org/obo/HINO_0017819
Preferred Name

Interaction of Csk with PAG
Definitions
Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Csk is a tyrosine kinase that phosphorylates the negative regulatory C-terminal tyrosine residue Y505 of Lck to maintain Lck in an inactive state. In resting T cells, Csk is targeted to lipid rafts through engagement of its SH2 domain with phosphotyrosine residue pY317 of PAG. PAG is expressed as a tyrosine phosphorylated protein in nonstimulated T-cells. This interaction of Csk and PAG allows activation of Csk and inhibition of Lck. Given that PAG-1 T cell knock out show a weak phenotype, some other protein may substitute in activating Csk.
Type http://www.w3.org/2002/07/owl#Class

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label
Interaction of Csk with PAG
comment
Reviewed: Trowsdale, J, 2008-02-26 12:02:59
Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
Csk is a tyrosine kinase that phosphorylates the negative regulatory C-terminal tyrosine residue Y505 of Lck to maintain Lck in an inactive state. In resting T cells, Csk is targeted to lipid rafts through engagement of its SH2 domain with phosphotyrosine residue pY317 of PAG. PAG is expressed as a tyrosine phosphorylated protein in nonstimulated T-cells. This interaction of Csk and PAG allows activation of Csk and inhibition of Lck. Given that PAG-1 T cell knock out show a weak phenotype, some other protein may substitute in activating Csk.
prefLabel
Interaction of Csk with PAG
definition source
Pubmed11827988
Reactome, http://www.reactome.org
Pubmed12938237
Pubmed10790433
prefixIRI
HINO:0017819
seeAlso
ReactomeREACT_12603
Reactome Database ID Release 43203774
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