Link to this page
Human Interaction Network Ontology
| Preferred Name | AKT interacts and phosphorylates Cot | |
| Synonyms |
|
|
| Definitions |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 Cot/Tpl 2 is a serine/threonine kinase of the mitogen activated protein kinase kinase kinase (MAP3K) family. Cot is observed as one of the downstream effectors of Akt. Based on in-vitro kinase assays and following overexpression in cell lines its been showed that AKT can phosphorylate Cot under non-physiological conditions. Akt and Cot physically interact through the amino terminus of Cot, and this interaction results in the phosphorylation of Cot on serine 400. Cot was shown to activate the IkB kinase (IKK) complex, possibly acting through NF kB inducing kinase (NIK). |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0017804 |
|
| comment |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 Cot/Tpl 2 is a serine/threonine kinase of the mitogen activated protein kinase kinase kinase (MAP3K) family. Cot is observed as one of the downstream effectors of Akt. Based on in-vitro kinase assays and following overexpression in cell lines its been showed that AKT can phosphorylate Cot under non-physiological conditions. Akt and Cot physically interact through the amino terminus of Cot, and this interaction results in the phosphorylation of Cot on serine 400. Cot was shown to activate the IkB kinase (IKK) complex, possibly acting through NF kB inducing kinase (NIK).
|
|
| definition source |
Reactome, http://www.reactome.org Pubmed12138205
|
|
| has input | ||
| has output | ||
| label |
AKT interacts and phosphorylates Cot
|
|
| prefixIRI |
HINO:0017804
|
|
| prefLabel |
AKT interacts and phosphorylates Cot
|
|
| seeAlso |
ReactomeREACT_19232 EC Number: 2.7.11 Reactome Database ID Release 43389756
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |