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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | CD28 bound PI3K phosphorylates PIP2 to PIP3 | |
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| Definitions |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 PI3K enzyme bound to co-stimulatory protein CD28 catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017803 |
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| comment |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 PI3K enzyme bound to co-stimulatory protein CD28 catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB.
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| definition source |
Pubmed12660731 Reactome, http://www.reactome.org
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| label |
CD28 bound PI3K phosphorylates PIP2 to PIP3
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| prefixIRI |
HINO:0017803
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| prefLabel |
CD28 bound PI3K phosphorylates PIP2 to PIP3
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| seeAlso |
Reactome Database ID Release 43389158 EC Number: 2.7.1.153 ReactomeREACT_19274
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