loading...| Preferred Name | Activation of TAK1-TAB2 complex | |
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has a Stoichiometric coefficient of 2 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta. |
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http://purl.obolibrary.org/obo/HINO_0017791 |
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| comment |
has a Stoichiometric coefficient of 2 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta. |
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| definition source |
Pubmed17496917 Reactome, http://www.reactome.org Pubmed16056267 Pubmed15125833 |
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http://purl.obolibrary.org/obo/HINO_0009065 |
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Activation of TAK1-TAB2 complex |
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| prefixIRI |
HINO:0017791 |
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| prefLabel |
Activation of TAK1-TAB2 complex |
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| seeAlso |
Reactome Database ID Release 43202510 ReactomeREACT_12518 EC Number: 2.7.11 |
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