loading...| Preferred Name | Auto-ubiquitination of TRAF6 | |
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| Definitions |
has a Stoichiometric coefficient of 3 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 TRAF6 possesses ubiquitin ligase activity and undergoes K-63-linked auto-ubiquitination after its oligomerization. In the first step, ubiquitin is activated by an E1 ubiquitin activating enzyme. The activated ubiquitin is transferred to a E2 conjugating enzyme (a heterodimer of proteins Ubc13 and Uev1A) forming the E2-Ub thioester. Finally, in the presence of ubiquitin-protein ligase E3 (TRAF6, a RING-domain E3), ubiquitin is attached to the target protein (TRAF6 on residue Lysine 124) through an isopeptide bond between the C-terminus of ubiquitin and the epsilon-amino group of a lysine residue in the target protein. In contrast to K-48-linked ubiquitination that leads to the proteosomal degradation of the target protein, K-63-linked polyubiquitin chains act as a scaffold to assemble protein kinase complexes and mediate their activation through proteosome-independent mechanisms. This K63 polyubiquitinated TRAF6 activates the TAK1 kinase complex. Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Edited: Garapati, P V, 2010-11-08 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017790 |
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| comment |
has a Stoichiometric coefficient of 3 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 TRAF6 possesses ubiquitin ligase activity and undergoes K-63-linked auto-ubiquitination after its oligomerization. In the first step, ubiquitin is activated by an E1 ubiquitin activating enzyme. The activated ubiquitin is transferred to a E2 conjugating enzyme (a heterodimer of proteins Ubc13 and Uev1A) forming the E2-Ub thioester. Finally, in the presence of ubiquitin-protein ligase E3 (TRAF6, a RING-domain E3), ubiquitin is attached to the target protein (TRAF6 on residue Lysine 124) through an isopeptide bond between the C-terminus of ubiquitin and the epsilon-amino group of a lysine residue in the target protein. In contrast to K-48-linked ubiquitination that leads to the proteosomal degradation of the target protein, K-63-linked polyubiquitin chains act as a scaffold to assemble protein kinase complexes and mediate their activation through proteosome-independent mechanisms. This K63 polyubiquitinated TRAF6 activates the TAK1 kinase complex. Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Edited: Garapati, P V, 2010-11-08 |
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| definition source |
Reactome, http://www.reactome.org Pubmed17135271 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0005603 |
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| label |
Auto-ubiquitination of TRAF6 |
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| prefixIRI |
HINO:0017790 |
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| prefLabel |
Auto-ubiquitination of TRAF6 |
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| seeAlso |
Reactome Database ID Release 43202453 EC Number: 6.3.2.19 ReactomeREACT_12595 |
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