has a Stoichiometric coefficient of 2 Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains.

http://purl.obolibrary.org/obo/HINO_0017787

has a Stoichiometric coefficient of 2

Authored: Garapati, P V, 2008-12-16 11:12:19

Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33

Edited: Garapati, P V, 2008-12-16 11:12:19

The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains.

Reactome, http://www.reactome.org

Pubmed8946678

Pubmed9973466

http://purl.obolibrary.org/obo/HINO_0024966

http://purl.obolibrary.org/obo/HINO_0009095

http://purl.obolibrary.org/obo/CHEBI_15422

http://purl.obolibrary.org/obo/HINO_0011808

http://purl.obolibrary.org/obo/CHEBI_16761

Phosphorylation of CD28

HINO:0017787

Phosphorylation of CD28

ReactomeREACT_19264

Reactome Database ID Release 43388831

EC Number: 2.7.10

http://purl.obolibrary.org/obo/INO_0000040