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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | CD28 homodimer binds B7-2 monomer | |
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| Definitions |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 CD28 delivers the costimulatory signal by interacting with its ligand B7-2 on the antigen-presenting cell and modulates T cell antigen recognition. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligand B7-2. Engagement of CD28 with B7-1 and with B7-2 have different bilogical functions in-vivo. Rapid dissociation of B7-2 from CD28 may not permit the robust tyrosine phosphorylation that the prolonged binding of B7-1 induces. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017786 |
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| comment |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 CD28 delivers the costimulatory signal by interacting with its ligand B7-2 on the antigen-presenting cell and modulates T cell antigen recognition. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligand B7-2. Engagement of CD28 with B7-1 and with B7-2 have different bilogical functions in-vivo. Rapid dissociation of B7-2 from CD28 may not permit the robust tyrosine phosphorylation that the prolonged binding of B7-1 induces.
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| definition source |
Reactome, http://www.reactome.org Pubmed8649453 Pubmed8609386
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| label |
CD28 homodimer binds B7-2 monomer
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| prefixIRI |
HINO:0017786
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| prefLabel |
CD28 homodimer binds B7-2 monomer
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| seeAlso |
ReactomeREACT_19240 Reactome Database ID Release 43388808
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