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Human Interaction Network Ontology
| Preferred Name | CD28 homodimer binds B7-1 homodimer | |
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| Definitions |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 A costimulatory signal involved in T cell activation is transmitted by CD28. This signal is delivered by the interaction of the CD28 receptor on T cells with its ligand B7-1 on the antigen-presenting cell and modulates T cell antigen recognition. Despite the homodimeric structure of CD28, it interacts with B7-1 as though it has a single binding site. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligands. B7-1 and B7-2 bind to overlapping but not identical sites on CD28 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017785 |
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| comment |
Authored: Garapati, P V, 2008-12-16 11:12:19 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 Edited: Garapati, P V, 2008-12-16 11:12:19 A costimulatory signal involved in T cell activation is transmitted by CD28. This signal is delivered by the interaction of the CD28 receptor on T cells with its ligand B7-1 on the antigen-presenting cell and modulates T cell antigen recognition. Despite the homodimeric structure of CD28, it interacts with B7-1 as though it has a single binding site. The V-like domains of CD28 contains a strictly conserved MYPPPY sequence motif that maps to the CDR3-analogous loop and is critical for recognition of its ligands. B7-1 and B7-2 bind to overlapping but not identical sites on CD28
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| definition source |
Reactome, http://www.reactome.org Pubmed8649453 Pubmed8609386
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| label |
CD28 homodimer binds B7-1 homodimer
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| prefixIRI |
HINO:0017785
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| prefLabel |
CD28 homodimer binds B7-1 homodimer
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| seeAlso |
ReactomeREACT_19148 Reactome Database ID Release 43388811
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