has a Stoichiometric coefficient of 2 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 NF-kB is a family of transcription factors that play pivotal roles in immune, inflammatory, and antiapoptotic responses. NF-kB/Rel family include five members, p65 (RelA), RelB, c-Rel, p50/p105 (NF-kB1) and p52/p100 (NF-kB2), exist in unstimulated cells as homo or heterodimers. NF-kB is sequestered in the cytosol of unstimulated cells through the interactions with a class of inhibitor proteins, called IkBs, which mask the nuclear localization signal of NF-kB and prevent its nuclear translocation. Various stimuli induce the activation of the IkB kinase (IKK) complex, which then phosphorylates IkBs. The phosphorylated IkBs are ubiquitinated and then degraded through the proteasome-mediated pathway. The degradation of IkBs releases NF-kB to translocate into nucleus and induces the expression of various genes. <br>The phosphorylation and ubiquitination of IkB kinase complex is mediated by two distinct pathways, either the classical or alternative pathway. In the classical NF-kB signaling pathway, the activated IKK complex, predominantly acting through IKK beta in an IKK gamma-dependent manner, catalyzes the phosphorylation of IkBs (at sites equivalent to Ser32 and Ser36 of IkB-alpha or Ser19 and Ser22 of IkB-beta), polyubiquitination (at sites equivalent to Lys21 and Lys22 of IkB-alpha) and subsequent degradation by the 26S proteasome. The K-48 ubiquitination is mediated by the E2 ubiquitin ligases (or SCFs) formed by three subunits: Skp1, Cul A (Cdc53), and one of many F-box proteins. Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10

http://purl.obolibrary.org/obo/HINO_0017784

has a Stoichiometric coefficient of 2

Reviewed: Trowsdale, J, 2008-02-26 12:02:59

NF-kB is a family of transcription factors that play pivotal roles in immune, inflammatory, and antiapoptotic responses. NF-kB/Rel family include five members, p65 (RelA), RelB, c-Rel, p50/p105 (NF-kB1) and p52/p100 (NF-kB2), exist in unstimulated cells as homo or heterodimers. NF-kB is sequestered in the cytosol of unstimulated cells through the interactions with a class of inhibitor proteins, called IkBs, which mask the nuclear localization signal of NF-kB and prevent its nuclear translocation. Various stimuli induce the activation of the IkB kinase (IKK) complex, which then phosphorylates IkBs. The phosphorylated IkBs are ubiquitinated and then degraded through the proteasome-mediated pathway. The degradation of IkBs releases NF-kB to translocate into nucleus and induces the expression of various genes.
The phosphorylation and ubiquitination of IkB kinase complex is mediated by two distinct pathways, either the classical or alternative pathway. In the classical NF-kB signaling pathway, the activated IKK complex, predominantly acting through IKK beta in an IKK gamma-dependent manner, catalyzes the phosphorylation of IkBs (at sites equivalent to Ser32 and Ser36 of IkB-alpha or Ser19 and Ser22 of IkB-beta), polyubiquitination (at sites equivalent to Lys21 and Lys22 of IkB-alpha) and subsequent degradation by the 26S proteasome. The K-48 ubiquitination is mediated by the E2 ubiquitin ligases (or SCFs) formed by three subunits: Skp1, Cul A (Cdc53), and one of many F-box proteins.

Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10

Reactome, http://www.reactome.org

Pubmed15371334

Pubmed17363905

Pubmed9252186

Pubmed15145317

http://purl.obolibrary.org/obo/HINO_0020423

http://purl.obolibrary.org/obo/CHEBI_15422

http://purl.obolibrary.org/obo/UniProt_P25963

http://purl.obolibrary.org/obo/CHEBI_16761

http://purl.obolibrary.org/obo/HINO_0020430

Activation of NF-kB complex

HINO:0017784

Activation of NF-kB complex

ReactomeREACT_12399

EC Number: 2.7.11

Reactome Database ID Release 43202541

http://purl.obolibrary.org/obo/INO_0000040