loading...| Preferred Name | Ubiquitination of NEMO by TRAF6 | |
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| Definitions |
During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Residues Lysine 321 and Lysine 326 may be few of the potent ubiquitination sites in NEMO. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017783 |
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| comment |
During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Residues Lysine 321 and Lysine 326 may be few of the potent ubiquitination sites in NEMO. Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 |
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| definition source |
Pubmed17728323 Reactome, http://www.reactome.org Pubmed17047224 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0005603 |
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| label |
Ubiquitination of NEMO by TRAF6 |
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| prefixIRI |
HINO:0017783 |
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| prefLabel |
Ubiquitination of NEMO by TRAF6 |
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| seeAlso |
EC Number: 6.3.2.19 Reactome Database ID Release 43202534 ReactomeREACT_12553 |
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