loading...| Preferred Name | Transfer of ubiquitin from E1 to E2 | |
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| Definitions |
Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017772 |
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| comment |
Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002). |
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| definition source |
Pubmed19940261 Pubmed19851334 Reactome, http://www.reactome.org Pubmed11917093 Pubmed19452197 |
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| label |
Transfer of ubiquitin from E1 to E2 |
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| prefixIRI |
HINO:0017772 |
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| prefLabel |
Transfer of ubiquitin from E1 to E2 |
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| seeAlso |
Reactome Database ID Release 43983152 ReactomeREACT_75860 |
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