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Human Interaction Network Ontology
| Preferred Name | E1 mediated ubiquitin activation | |
| Synonyms |
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| Definitions |
Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017770 |
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| comment |
Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29
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| definition source |
Reactome, http://www.reactome.org Pubmed19352404 Pubmed18662542 Pubmed16595681
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| has input |
http://purl.obolibrary.org/obo/CHEBI_18420 http://purl.obolibrary.org/obo/HINO_0019325 |
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| has output |
http://purl.obolibrary.org/obo/CHEBI_18420 http://purl.obolibrary.org/obo/HINO_0009677 |
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| label |
E1 mediated ubiquitin activation
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| prefixIRI |
HINO:0017770
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| prefLabel |
E1 mediated ubiquitin activation
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| seeAlso |
ReactomeREACT_75782 EC Number: 6.3.2.19 Reactome Database ID Release 43983153
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