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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0017768
http://purl.obolibrary.org/obo/HINO_0017768
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|---|---|
| Preferred Name | Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation |
| Definitions |
RasGRP1 and RasGRP3 translocate to the plasma membrane where they bind diacylglycerol (Lorenzo et al. 2001) and are phosphorylated (Teixeira et al. 2003, Zheng et al. 2005). Though RasGRP3 is phosphorylated in vitro and in some cell lines (e.g. Ramos cells) by protein kinase C theta (PKC-theta, Zheng et al. 2005), normal B cells do not contain PKC-theta (Meller et al. 1999). Both Rasgrp1 and Rasgrp3 participate in activating Ras in response to BCR signaling in mouse B cells (Coughlin et al. 2005).
Edited: May, B, 2010-12-09
Authored: May, B, 2011-01-03
Reviewed: Wienands, J, 2012-02-11
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation
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| comment |
RasGRP1 and RasGRP3 translocate to the plasma membrane where they bind diacylglycerol (Lorenzo et al. 2001) and are phosphorylated (Teixeira et al. 2003, Zheng et al. 2005). Though RasGRP3 is phosphorylated in vitro and in some cell lines (e.g. Ramos cells) by protein kinase C theta (PKC-theta, Zheng et al. 2005), normal B cells do not contain PKC-theta (Meller et al. 1999). Both Rasgrp1 and Rasgrp3 participate in activating Ras in response to BCR signaling in mouse B cells (Coughlin et al. 2005).
Edited: May, B, 2010-12-09
Authored: May, B, 2011-01-03
Reviewed: Wienands, J, 2012-02-11
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| prefLabel |
Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation
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| definition source |
Pubmed10222061
Pubmed16301621
Reactome, http://www.reactome.org
Pubmed11221888
Pubmed12730099
Pubmed15657177
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| prefixIRI |
HINO:0017768
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| seeAlso |
Reactome Database ID Release 431168374
ReactomeREACT_118733
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| has output |
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